ODCs

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1 associated gene
No signs/symptoms info

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
12 signs/symptoms

Leydig cell hypoplasia due to LHB deficiency

Familial male-limited precocious puberty


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	LHB	(0.52)	LHCGR

Citations in the biomedical literature:

Leydig cell hypoplasia due to LHB deficiency		Familial male-limited precocious puberty
	Synonym(s): - 46,XY DSD due to LHB deficiency - 46,XY DSD due to luteinizing hormone subunit beta deficiency - 46,XY disorder of sex development due to LHB deficiency - 46,XY disorder of sex development due to luteinizing hormone subunit beta deficiency - Leydig cell hypoplasia due to luteinizing hormone subunit beta deficiency		Synonym(s): - FMPP - Familial gonadotropin-independent male-limited sexual precocity - Male-limited precocious puberty - Testotoxicosis

	Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare infertility - Rare urogenital disease		Classification (Orphanet): - Rare endocrine disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: (no data available)		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: normal Type of inheritance: autosomal dominant

	External references: No OMIM references No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: C536961

Familial male-limited precocious puberty
	Very frequent - Advanced bone age - Autosomal dominant inheritance - Precocious puberty - Sterility / hypofertility - Tall stature / gigantism / growth acceleration Frequent - Acne / acnea - Hair and scalp anomalies - Macropenis / megapenis / large penis Occasional - Azoospermia / oligospermia / asthenospermia - Hyperactivity / attention deficit - Macroorchidism / macrotestes - Psychic / behavioural troubles
Leydig cell hypoplasia due to LHB deficiency
(no data available)